Embodiments of the present disclosure provide a protection circuit and method, a pixel circuit, and a display device. The protection circuit comprises a determination circuit, a first coupling circuit, a first terminal and a second terminal. The determination circuit is coupled to the first terminal and the first coupling circuit, and is configured to determine whether the voltage at the first terminal of the protection circuit belongs to one of a first predetermined range and a second predetermined range. The first coupling circuit is coupled to the first terminal, the second terminal and the determination circuit, and is configured to: couple the first terminal to the second terminal in response to the voltage at the first terminal belonging to the first predetermined range; and decouple the first terminal from the second terminal in response to the voltage at the first terminal belonging to the second predetermined range.