The present disclosure provides a registration method and communication method for an Application Dedicated Node (ADN), and nodes, and relates to the field of Machine Type Communication (MTC). A Common Service Entity of a Middle Node (MN-CSE) creates an application dedicated resource for an Application Entity of the ADN (ADN-AE), and announces the application dedicated resource to a CSE of an Infrastructure Node (IN-CSE). The IN-CSE creates an announcement resource corresponding to the application dedicated resource. The IN-CSE determines the application dedicated resource corresponding to the announcement resource according to the ADN-AE which an IN-AE requests to operate, and establishes a connection with the MN-CSE. The MN-CSE establishes a connection with the ADN-AE through the application dedicated resource.