Invention Grant
- Patent Title: Heteroaromatic modulators of the retinoid-related orphan receptor gamma
-
Application No.: US16317655Application Date: 2017-07-11
-
Publication No.: US10662181B2Publication Date: 2020-05-26
- Inventor: Alan Stuart Jessiman , Patrick Stephen Johnson , Kristoffer Maansson , Morten Dahl Sørensen
- Applicant: LEO PHARMA A/S
- Applicant Address: DK Ballerup
- Assignee: LEO Pharma A/S
- Current Assignee: LEO Pharma A/S
- Current Assignee Address: DK Ballerup
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@280d1c5e
- International Application: PCT/EP2017/067390 WO 20170711
- International Announcement: WO2018/011201 WO 20180118
- Main IPC: C07D413/12
- IPC: C07D413/12 ; C07D413/14 ; C07D417/14 ; C07D241/04

Abstract:
The present invention relates to a compound according to general formula (I) wherein X represents N or CH; R1 is —CN, (C1-C6)alkyl, (C3-C7)cycloalkyl, (3-7 membered)heterocycloalkyl, (5-6 membered)heteroaryl, (C3-C7)cycloalkyl(C1-C4)alkyl, (3-7 membered)heterocycloalkyl-(C1-C4)alkyl or (5-6 membered)heteroaryl-(C1-C4)alkyl; R2 is halogen, cyano, (C1-C4)alkyl or (C3-C7)cycloalkyl; R3 is halogen, cyano, (C1-C4)alkyl, (C1-C4)haloalkyl or (C3-C7)cycloalkyl; R4 is (C1-C4)alkyl or (C1-C4)haloalkyl; R5 is (C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C6)alkyl-(C3-C7)cycloalkyl, (C3-C7)cycloalkyl-(C1-C6)alkyl, (3-7 membered)heterocycloalkyl, phenyl, (5-6 membered)heteroaryl or —ORa. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds and to intermediates for preparation of said compounds.
Public/Granted literature
- US20190284177A1 HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA Public/Granted day:2019-09-19
Information query