Systems and methods for automated contact deletion based on content communications are disclosed herein. Based on a content item electronically communicated from a source account to a destination account, a contact deletion trigger is generated to define a criterion for deleting a contact entry that identifies the source account and is stored for the destination account in a contact database. Based on the contact deletion trigger, a determination is made as to whether the criterion for deleting the contact entry has been met. In response to determining that the criterion for deleting the contact entry has been met, the contact entry is automatically deleted from the contact database.