Techniques of reducing or eliminating artifact pixels in high dynamic range (HDR) imaging are described. One embodiment includes obtaining a first image of a scene at a first time with first exposure settings and obtaining a second image of the scene at a second time with second exposure settings that differ from the first exposure settings. The obtained images may be downsampled. The images may be compared to each other to assist with determining a number of potential artifact pixels in the scene. Depending on a relationship between the number of potential artifact pixels and a threshold value, the first image or second image may be selected as a reference image for registering the images with each other. A type of registration performed between the images may depend on which of the two images is the selected reference image. The registered images may be used to generate an HDR image.