An apparatus and method for determining a target adjustment route for a preset control condition set of a production line are provided. The apparatus establishes at least one candidate adjustment route for the preset control condition set according to the historical control condition sets. Each candidate adjustment route includes at least one adjustment control condition set arranged in an adjustment order. Each adjustment control condition set is one of the historical control condition sets. Within the same candidate adjustment route, the historical yield related values corresponding to the adjustment control condition sets are all greater than the preset yield related value and increase in the adjustment order. Within the same candidate adjustment route, the numbers of the adjustment control condition(s) included in the adjustment sets increase in the adjustment order. The apparatus selects one of the candidate adjustment route(s) as the target adjustment route.