In some embodiments, a memory initialization detection process includes detecting a read instruction of a program, where the read instruction addresses a particular memory location, and where data corresponding to the particular memory location is cached in a particular cache line of a memory cache. The memory initialization detection process further includes determining, based on metadata stored in the memory cache, that a section of the particular cache line does not store valid data of the program. The memory initialization detection process further includes obtaining validity data from the section of the particular cache line. The memory initialization detection process further includes determining, based on the validity data, whether the read instruction is authorized to proceed.