Disclosed and described systems, methods, and apparatus provide diagnostic display and analysis of patient data. An example radiology desktop system includes a workload manager that organizes and displays one or more worklists. The example workload manager retrieves and displays, based on receiving a selection of an active worklist, one or more exams associated with the active worklist. The example system includes a diagnostic hub triggered based on selection of an exam. The example diagnostic hub generates an exam preview panel provides a summary of the selected exam. The example diagnostic hub facilitates comparison, based on selection of a comparison exam via the user interface from a patient library, between the selected exam and the comparison exam via the diagnostic hub. The example diagnostic hub updates a worklist entry for the selected exam based on an analysis resulting from the comparison between the selected exam and the comparison exam.