An electrode structure is disclosed, including: a plurality of first electrodes, which transfer an electrical signal; and a plurality of second electrodes, which do not transfer the electrical signal, wherein the first electrode and the second electrode are electrically separated from each other, the second electrode and the first electrode are alternately arranged, each of the second electrodes includes electrodes electrically separated from each other, and in the electrodes electrically separated from each other, some separation borders not perpendicular to an extending direction of the first electrode can be connected to form an oblique connecting line with respect to the extending direction. Further, a method of manufacturing an electrode structure, a touch panel and a touch display device are disclosed.