A touch sensor system includes a touch panel, at least one multiplexer and a touch controller. The touch panel includes one or more touch sensing areas. The at least one multiplexer is coupled to the one or more touch sensing areas through one or more connecting wire groups on the touch panel, wherein each of the connecting wire groups includes one or more connecting wires. The touch controller is coupled to the at least one multiplexer via one or more touch control wires and one or more touch sensing wires. Each of the at least one multiplexer includes one or more switch groups each coupled between one of the one or more touch sensing wires and one of the connecting wire groups, and each of the switch groups includes one or more switches respectively controlled by one or more control signals transmitted through the one or more touch control wires.