Invention Grant
- Patent Title: Substituted quinolone derivatives, or pharmaceutically acceptable salts or stereoisomers thereof, and pharmaceutical compositions and use thereof
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Application No.: US15752896Application Date: 2016-08-18
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Publication No.: US10683278B2Publication Date: 2020-06-16
- Inventor: Ke Ding , Meiyu Geng , Li Tan , Jian Ding , Zhang Zhang , Jing Ai , Xiaomei Ren , Donglin Gao , Zhengchao Tu , Xiaoyun Lu , Dongmei Zhang
- Applicant: JINAN UNIVERSITY , SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- Applicant Address: CN Shanghai CN Guangdong CN Pudong, Shanghai
- Assignee: SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.,JINAN UNIVERSITY,SHANGHAI INTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- Current Assignee: SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.,JINAN UNIVERSITY,SHANGHAI INTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- Current Assignee Address: CN Shanghai CN Guangdong CN Pudong, Shanghai
- Agency: JMB Davis Ben-David
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@5145407a
- International Application: PCT/CN2016/095813 WO 20160818
- International Announcement: WO2017/028797 WO 20170223
- Main IPC: A61K31/4709
- IPC: A61K31/4709 ; C07D215/233 ; C07D401/12 ; C07D471/04 ; C07D471/06 ; C07D487/04 ; C07D491/048 ; C07D498/06 ; C07D513/04 ; C07D519/00
Abstract:
Provided are a substituted quinolone derivative as shown by formula (I), or a pharmaceutically acceptable salt and a prodrug molecule thereof, and a pharmaceutical composition thereof, as well as the use of same in preparing drugs for the prevention and treatment of a tumor. The quinolone derivative, salt, prodrug molecule, and pharmaceutical composition thereof can be used as a protein kinase inhibitor, which is effective in inhibiting the activity of AXL protein kinase, and is capable of inhibiting the proliferation, migration and invasion of various tumor cells; and can be used in the preparation of anti-tumor drugs, especially drugs for treating hyperproliferative diseases such as a tumor in human beings and other mammals.
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