A liquid discharge device includes a case receiving a cartridge having a first liquid chamber, a tank having a second liquid chamber, a head, a liquid level sensor and a controller configured to: receive a first signal or a second signal when a position of a liquid level in the second liquid chamber is equal to or higher than or lower than a predetermined position; prohibit a liquid discharge through the head in a predetermined case; cancel the prohibition of the liquid discharge based on determining that the cartridge is installed in the case; and prohibit the liquid discharge based on determining that a first elapsed time from a time when determining that the cartridge is installed in the installation case reaches a predetermined time and the second signal is received from the liquid level sensor without receiving the first signal.