Invention Grant
- Patent Title: Thieno[2,3-b]pyridine derivative, quinoline derivative, and use thereof
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Application No.: US16306696Application Date: 2017-06-14
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Publication No.: US10689394B2Publication Date: 2020-06-23
- Inventor: Hidenori Ichijo , Kengo Homma , Naomi Tsuburaya , Tetsuo Nagano , Takayoshi Okabe , Hirotatsu Kojima , Manabu Shimonishi , Takao Fujisawa , Norio Shiibata , Tsunehiko Higuchi , Seiichi Nakamura , Hidehiko Nakagawa , Shin-Ichi Ikeda
- Applicant: The University of Tokyo
- Applicant Address: JP Tokyo
- Assignee: THE UNIVERSITY OF TOKYO
- Current Assignee: THE UNIVERSITY OF TOKYO
- Current Assignee Address: JP Tokyo
- Agency: Westerman, Hattori, Daniels & Adrian, LLP
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@441c267a
- International Application: PCT/JP2017/021895 WO 20170614
- International Announcement: WO2017/217439 WO 20171221
- Main IPC: C07D495/04
- IPC: C07D495/04 ; C07D401/04 ; A61P21/02 ; A61K31/4365 ; A61P21/00
![Thieno[2,3-b]pyridine derivative, quinoline derivative, and use thereof](/abs-image/US/2020/06/23/US10689394B2/abs.jpg.150x150.jpg)
Abstract:
A compound represented by the following formula (1) is provided: wherein X represents a sulfur atom or —CH═CH—; A1 to A4 each independently represent a carbon atom or a nitrogen atom, and at least one of A1 to A4 is a nitrogen atom; R1 represents any one of a 1,2,3,4-tetrahydroquinolyl group (or a 3,4-dihydro-1(2H)-quinolyl group), a 3,4-dihydro-4,4-dimethyl-1(2H)-quinolyl group, a 2,3,4,5-tetrahydro-1H-1-benzazepinyl group, or a substituent represented by the following formula (2): wherein R4 represents a 2,3,4-trifluorophenyl group, a 4-iodophenyl group, a 2,3-difluorophenyl group, a 3,5-difluorophenyl group, a 5-fluoro-2-methylphenyl group, a 3-pentafluorosulfanylphenyl group, a 2,6-dimethylphenyl group, a 4-benzyloxyphenyl group, a 3,5-bis(trifluoromethyl)biphenyl group, a 4-tert-butylphenyl group, a 3-methoxyphenyl group, an unsubstituted or substituted pyridyl group, or an unsubstituted or substituted naphthyl group; R5 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group optionally containing an oxygen atom and/or a double bond, or an unsubstituted or substituted aromatic lower alkyl group; R2 represents a hydrogen atom, a lower alkyl group, a lower acyl group, or an unsubstituted or substituted aromatic lower alkyl group; and R3 represents a hydrogen atom, or R2 and R3 may bind to each other to form a ring.
Public/Granted literature
- US20190177336A1 THIENO[2,3-b]PYRIDINE DERIVATIVE AND QUINOLINE DERIVATIVE, AND USE THEREOF Public/Granted day:2019-06-13
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