Invention Grant
- Patent Title: Microorganisms for diterpene production
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Application No.: US14893216Application Date: 2014-06-02
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Publication No.: US10689681B2Publication Date: 2020-06-23
- Inventor: Viktor Marius Boer , Erwin Suir
- Applicant: DSM IP ASSETS B.V.
- Applicant Address: NL Heerlen
- Assignee: DSM IP ASSETS B.V.
- Current Assignee: DSM IP ASSETS B.V.
- Current Assignee Address: NL Heerlen
- Agency: McBee Moore & Vanik IP, LLC
- International Application: PCT/EP2014/061399 WO 20140602
- International Announcement: WO2014/191581 WO 20141204
- Main IPC: C12P19/56
- IPC: C12P19/56 ; C12N9/88 ; C12N9/02 ; C12N9/16 ; C12N15/52 ; C12N9/90 ; C07K14/39 ; C12N9/10 ; C12N9/24 ; A23L27/30 ; A23L2/60 ; C07K14/395 ; C12P15/00 ; C07H15/256

Abstract:
The present invention relates to a recombinant microorganism comprising one or more nucleotide sequence(s) encoding: a polypeptide having ent-copalyl pyrophosphate synthase activity; a polypeptide having ent-Kaurene synthase activity; a polypeptide having ent-Kaurene oxidase activity; and a polypeptide having kaurenoic acid 13-hydroxylase activity, whereby expression of the nucleotide sequence(s) confer(s) on the microorganism the ability to produce at least steviol. The recombinant microorganism may also be capable of expressing one or more UDP-glucosyltransferases such that the microorganism is capable of producing one or more steviol glycosides.
Public/Granted literature
- US20160177360A1 MICROORGANISMS FOR DITERPENE PRODUCTION Public/Granted day:2016-06-23
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