A bytecode construction, a method, and a system for optimizing just in time compilation. The bytecode includes several regions wherein a region is a logical sequence of one or more bytecode blocks and the bytecode is annotated with region hints embedded therein. The region hints have a bytecode structure and are designed for instructing a just-in-time, or JIT, runtime environment for JIT compilation of the regions by JIT compilers implemented at nodes of a network. A method and a system for implementing the bytecode construction are also presented.