Invention Grant
![Benzo[b]thiophene compounds as STING agonists](/docs/US/2020-07-07/US10703738B2/abs.jpg.600x600.jpg)
- Patent Title: Benzo[b]thiophene compounds as STING agonists
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Application No.: US16513409Application Date: 2019-07-16
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Publication No.: US10703738B2Publication Date: 2020-07-07
- Inventor: Michael D. Altman , Brandon D. Cash , Wonsuk Chang , Jared N. Cumming , Andrew M. Haidle , Timothy J. Henderson , James P. Jewell , Matthew A. Larsen , Rui Liang , Jongwon Lim , Min Lu , Ryan D. Otte , Tony Siu , Benjamin Wesley Trotter , Sriram Tyagarajan
- Applicant: MERCK SHARP & DOHME CORP.
- Applicant Address: US NY Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NY Rahway
- Agent Julie M. Lake; Catherine D. Fitch
- Main IPC: C07D333/60
- IPC: C07D333/60 ; C07D333/62 ; C07D409/12 ; C07D498/04
![Benzo[b]thiophene compounds as STING agonists](/abs-image/US/2020/07/07/US10703738B2/abs.jpg.150x150.jpg)
Abstract:
Compounds of general formula (Ia), compounds of general formula (Ia′), compounds of general formula (Ib), compounds of general formula (Ib′), compounds of general formula (I), compounds of general formula (I′), and their pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, R6, R8, R9, X1, X2, and X3 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds of the disclosure.
Public/Granted literature
- US20190337917A1 BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS Public/Granted day:2019-11-07
Information query
