![Benzo[b]thiophene compounds as STING agonists](/docs/US/2020-07-07/US10703738B2/abs.jpg.600x600.jpg)
- 专利标题： Benzo[b]thiophene compounds as STING agonists
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申请号： US16513409申请日： 2019-07-16
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公开(公告)号： US10703738B2公开(公告)日： 2020-07-07
- 发明人: Michael D. Altman , Brandon D. Cash , Wonsuk Chang , Jared N. Cumming , Andrew M. Haidle , Timothy J. Henderson , James P. Jewell , Matthew A. Larsen , Rui Liang , Jongwon Lim , Min Lu , Ryan D. Otte , Tony Siu , Benjamin Wesley Trotter , Sriram Tyagarajan
- 申请人： MERCK SHARP & DOHME CORP.
- 申请人地址： US NY Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NY Rahway
- 代理商 Julie M. Lake; Catherine D. Fitch
- 主分类号： C07D333/60
- IPC分类号： C07D333/60 ; C07D333/62 ; C07D409/12 ; C07D498/04
![Benzo[b]thiophene compounds as STING agonists](/abs-image/US/2020/07/07/US10703738B2/abs.jpg.150x150.jpg)
摘要：
Compounds of general formula (Ia), compounds of general formula (Ia′), compounds of general formula (Ib), compounds of general formula (Ib′), compounds of general formula (I), compounds of general formula (I′), and their pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, R6, R8, R9, X1, X2, and X3 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds of the disclosure.
公开/授权文献
- US20190337917A1 BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS 公开/授权日：2019-11-07