The present disclosure includes systems and methods for reducing intra-cell interference during uplink MU-MIMO. An uplink grant that allocates a plurality of resource blocks is obtained. A first portion of the plurality of RBs that are overlapping with a set of RBs granted to a second UE is determined. A second portion of the plurality of RBs that are non-overlapping with the set of RBs granted to the second UE is also determined. A first demodulation reference signal (DMRS) sequence is generated for the first portion of the plurality of RBs. A second DMRS sequence is generated for the second portion of the plurality of RBs, where the second DMRS sequence is different than the first DMRS sequence. An uplink transmission (e.g., PUCCH, PUSCH) is generated that includes RBs having different DMRS sequences.