- 专利标题: FLT3 receptor inhibitor at low dosage for the treatment of neuropathic pain
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申请号: US16307968申请日: 2017-06-08
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公开(公告)号: US10709687B2公开(公告)日: 2020-07-14
- 发明人: Jean Valmier
- 申请人: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITE DE MONTPELLIER , BIODOL THERAPEUTICS
- 申请人地址: FR Paris FR Montpellier FR Clapiers
- 专利权人: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE),UNIVERSITE DE MONTPELLIER,BIODOL THERAPEUTICS
- 当前专利权人: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE),UNIVERSITE DE MONTPELLIER,BIODOL THERAPEUTICS
- 当前专利权人地址: FR Paris FR Montpellier FR Clapiers
- 代理机构: W&C IP
- 优先权: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@365656d2
- 国际申请: PCT/EP2017/063935 WO 20170608
- 国际公布: WO2017/211937 WO 20171214
- 主分类号: A61K31/404
- IPC分类号: A61K31/404 ; A61P25/02 ; A61P29/00 ; A61K9/00 ; A61K9/70 ; A61K31/497 ; A61K31/5377 ; A61K31/553 ; A61K31/44
摘要:
The present invention relates to FLT3 receptor inhibitor for use in the treatment of neuropathic pain and chronic pain comprising a neuropathic component, wherein the daily dosage range per human adult per day of said FLT3 receptor inhibitor consists of a dosage range determined by a method comprising the steps of: (i) determining the minimal inhibiting dose of said FLT3 receptor inhibitor that induces the maximal inhibition of mechanical pain hypersensitivity, (ii) converting said dose to the Human Equivalent Dose (HED) by the allometric correction method, and (iii) establishing a daily dosage range per human adult per day wherein (iii-1) the lower limit of the said daily dosage range per human adult per day is the greater value between HED/20 determined via a rat model and 0.001 mg, and (iii-2) the upper limit of the said daily dosage range is the lower value between HED*20 determined via a rat model and 50 mg.
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