Methods and systems are disclosed for symbol sequence generation and transmission for non-orthogonal multiple access (NoMA) transmission. A NoMA signal may be generated based on: (1) a first symbol sequence, the first symbol sequence determined from a set of input bits and associated with a first MA signature within a first MA signature space; (2) a second symbol sequence determined based on the first symbol sequence, the second symbol sequence being associated with a second MA signature within a second MA signature space; and (3) a symbol-to-resource element mapping applied to the second symbol sequence to produce the NoMA signal.