In one example in accordance with the present disclosure, a system for backup of a physical memory region of volatile memory. The system may include: a non-volatile memory, a volatile memory, at least one processor to: execute an application that indicates a virtual memory region stored in the volatile memory, wherein the virtual memory region is associated with an application, determine a corresponding physical memory region of the volatile memory for backup based on the indicated virtual memory region, and at least one memory controller to: receive a backup signal for the physical memory region of the volatile memory, and responsive to receiving the backup signal, backup up the physical memory region of the volatile memory to a memory region of the non-volatile memory.