A method for analyzing a program may include generating an initial control flow graph (CFG) for the program, identifying merge blocks of the initial CFG, identifying predecessor-merge pairs based on identifying predecessor blocks for each merge block, simulating a duplication of each predecessor-merge pair, determining whether the duplication satisfies a precondition of each of a collection of optimizations, applying, in response to satisfying the precondition, the optimization to the duplication, and generating a simulation result for the predecessor-merge pair corresponding to the duplication. The simulation result may include the optimization and a benefit of applying the optimization to the duplication. The method may further include duplicating, in the initial CFG, a predecessor-merge pair based on the simulation result corresponding to the predecessor-merge pair.