Invention Grant
- Patent Title: MDR-reversing 8-hydroxy-quinoline derivatives
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Application No.: US16091134Application Date: 2017-04-05
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Publication No.: US10744127B2Publication Date: 2020-08-18
- Inventor: Gergely Szakács , Tibor Soós , Roberta Ferenczi-Palkó , András Füredi , Szilárd Tóth , Dóra Türk , Veronika Pape , Ferenc Fülöp , István Szatmári , György Dormán
- Applicant: MAGYAR TUDOMÁNYOS AKADÉMIA TERMÉSZETTUDOMÁNYI KUTATÓKÖZPONT
- Applicant Address: HU Budapest
- Assignee: Magyar Tudományos Akadémia Természettudományi Kutatóközpont
- Current Assignee: Magyar Tudományos Akadémia Természettudományi Kutatóközpont
- Current Assignee Address: HU Budapest
- Agent Jason D. Voight
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@2651468d
- International Application: PCT/HU2017/050009 WO 20170405
- International Announcement: WO2017/175018 WO 20171012
- Main IPC: A61K31/4709
- IPC: A61K31/4709 ; C07D215/38 ; C07D401/04 ; C07D401/12 ; C07D417/12 ; C07D471/04 ; C07D495/04 ; A61K45/06 ; A61K31/47 ; C07D215/36 ; C07D401/14 ; A61P35/04 ; A61K31/4704 ; A61K31/4725 ; A61K31/498 ; C07D215/28
Abstract:
The present invention is related to 8-hydroxy-quinoline derivatives having multidrug-resistance reversing activity with improved selectivity and increased cytotoxicity towards multidrug-resistant cancer cells, preparation thereof and use of the same in the treatment of cancer, especially multidrug-resistant variants thereof.
Public/Granted literature
- US20190151306A1 MDR-REVERSING 8-HYDROXY-QUINOLINE DERIVATIVES Public/Granted day:2019-05-23
Information query
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