- 专利标题： Tetrahydronaphthyridine, benzoxazine, aza-benzoxazine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease
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申请号： US16270882申请日： 2019-02-08
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公开(公告)号： US10745364B2公开(公告)日： 2020-08-18
- 发明人: Thomas D. Aicher , Chad A. VanHuis , William D. Thomas , John K. MacLean , Brian M. Andresen , Kenneth J. Barr , Corey E. Bienstock , Neville J. Anthony , Matthew Daniels , Kun Liu , Yuan Liu , Catherine M. White , Blair T. Lapointe , Nunzio Sciammetta , Vladimir Simov
- 申请人： Merck Sharp & Dohme Corp. , Lycera Corporation
- 申请人地址： US MI Ann Arbor US NJ Rahway
- 专利权人： Lycera Corporation,Merck Sharp & Dohme Corp.
- 当前专利权人： Lycera Corporation,Merck Sharp & Dohme Corp.
- 当前专利权人地址： US MI Ann Arbor US NJ Rahway
- 代理机构： Dechert LLP
- 主分类号： C07D265/36
- IPC分类号： C07D265/36 ; C07D413/14 ; C07D215/58 ; C07D401/06 ; C07D401/12 ; C07D413/04 ; C07D471/04 ; A61K31/4375 ; A61K31/47 ; A61K31/4709 ; A61K31/538 ; A61K45/06 ; C07D413/06 ; C07D413/12 ; C07D417/06 ; C07D487/04
摘要：
The invention provides certain bicylic heterocyclic compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein X1, X2, R1, R2, R3, R4, and Cy are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds of the Formula (I) or pharmaceutically acceptable salts thereof, and methods of using the compounds of the Formula (I) or pharmaceutically acceptable salts thereof or pharmaceutical compositions comprising the same for treating diseases or conditions mediated by RORgammaT.
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