An actuating system of an engine valve comprises a movable member, for example, in the form of a master piston controlled by a cam of a camshaft. A slave piston is hydraulically controlled by the master piston by means of a volume of pressurized fluid, to open said engine valve against the action of a return spring. The system also comprises an auxiliary device for applying an additional force to the engine valve to keep the engine valve in a closed position. The auxiliary device is configured or controlled in such a way that the total force tending to keep the engine valve in its closed position varies during each rotation cycle of the cam. The total force is higher at least in one part of the rotation cycle of the cam wherein the engine valve must remain in its closed position, and is, instead, reduced at least in one part of the rotation cycle of the cam wherein the engine valve is not in its closed position.