A fluid-actuated diaphragm drive and a valve arrangement which is equipped therewith, wherein the diaphragm drive has a drive housing with two drive housing parts which are attached to one another axially. An insert body which preferably consists of plastic material and delimits at least one length section of an operating chamber which can be loaded with a fluid is inserted into each of the drive housing parts, wherein a drive diaphragm which is movement-coupled to an output member is clamped in between the two insert bodies. A seal structure which is active between at least one of the insert bodies and the drive housing is capable of preventing an axial flow around the two insert bodies in the region which lies radially between them and the drive housing.