An in-cell transparent touch display panel, manufacturing method and driving method thereof, which relates to the technical field of display is disclosed. The transparent touch display panel includes a first electrode and a pixel defining structure on a transparent substrate, the first electrode extending along a first direction and the pixel defining structure defining a plurality of pixel regions and touch electrode regions; an organic electroluminescent layer in the pixel regions, a second electrode arranged on the organic electroluminescent layer and in the pixel regions, the second electrodes extending along a second direction; and a plurality of first touch electrodes along the first direction and a plurality of second touch electrodes along the second direction and in the touch electrode regions. The first electrodes, second electrodes, first touch electrodes and second touch electrodes are all transparent electrodes, and the first direction intersects with the second direction.