Systems and methods for integrating cloud-based and cloud-backed content items with a content management system are provided. In some examples, a method can include receiving a request to open a cloud-backed content item at a first client device using a native application associated with the cloud-backed content item; detecting that the content item is open at a second client device from a cloud-based application that supports live collaboration for the cloud-backed content item; and directing the first client device to an instance of the cloud-based application at the first client device.