Methods and apparatus to configure switches of a virtual rack are disclosed. An example apparatus includes a hardware switch implementing a virtual switch on a virtual communication network, a packet analyzer to analyze a packet captured at the hardware switch, the packet analyzer to determine whether the packet is indicative of a packet flow issue corresponding to a negative effect on transfer of one or more packet flows on the virtual communication network, an issue handler to, in response to the determination by the packet analyzer, determine a modification to a configuration of the hardware switch based on a configuration of the virtual configuration network, and a hardware configuration agent to modify the configuration of the hardware switch based on the modification determined by the issue handler.