Described herein are systems, methods, and software to enhance the management of packet filters for host computing systems. In one implementation, a method of managing packet filters for a physical network interface on a host computing system includes obtaining dispatch statistics for media access control (MAC) addresses associated with virtual nodes communicating over the physical network interface via a virtual switch. After obtaining the dispatch statistics, the method further provides identifying a filter configuration based on the dispatch statistics, wherein the filter configuration classifies received packets at the physical network interface into processing queues based on attributes identified in the received packets, and applying the filter configuration in the physical network interface.