A method and apparatus for compensating and calibrating a bio-impedance measurement device are provided. In the method and apparatus, a memory stores a plurality of compensation parameters and a first detection channel receives a first detection signal, compensates the first detection signal using a first compensation parameter of the plurality of compensation parameters. In the method and apparatus, a second detection channel receives a second detection signal and a third detection signal and compensates the second and third detection signals using second and third compensation parameters of the plurality of compensation parameters and the compensated first detection signal. The impedance measurement device generates a first output signal representative of a first impedance measurement and a second output signal representative of a second impedance measurement based on the compensated first, second and third detection signals.