An actuation system, in particular for a vehicle brake, may include an actuating device, such as a brake pedal, at least one first pressure source, e.g., a piston-cylinder unit (master cylinder), which can be actuated in particular by means of the actuating device and a second pressure source, in particular a piston-cylinder unit, with an electro-mechanical drive. The pressure sources may each be connected to at least one brake circuit via a hydraulic line, in order to supply the brake circuit with pressurising medium and to pressurise the vehicle brake. There may further be a valve device for regulating the brake pressure. It is planned that during forward and return stroke at least one brake circuit can be fed controlled pressurising medium by way of the second pressure source.