- 专利标题： Chimeric antigen receptors targeting B-cell maturation antigen
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申请号： US15692473申请日： 2017-08-31
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公开(公告)号： US10767184B2公开(公告)日： 2020-09-08
- 发明人: James N. Kochenderfer
- 申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services
- 申请人地址： US MD Bethesda
- 专利权人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services
- 当前专利权人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services
- 当前专利权人地址： US MD Bethesda
- 代理机构： Leydig, Voit & Mayer
- 主分类号： C12N15/62
- IPC分类号： C12N15/62 ; C07K14/705 ; C07K14/725 ; C07K16/28 ; C07K16/18 ; A61K48/00 ; A61K39/00
摘要：
The invention provides an isolated and purified nucleic acid sequence encoding a chimeric antigen receptor (CAR) directed against B-cell Maturation Antigen (BCMA). The invention also provides host cells, such as T-cells or natural killer (NK) cells, expressing the CAR and methods for destroying multiple myeloma cells.
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