- 专利标题： 1-pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and compositions thereof for inhibiting the activity of SHP2
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申请号： US16117674申请日： 2018-08-30
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公开(公告)号： US10774065B2公开(公告)日： 2020-09-15
- 发明人: Christine Hiu-Tung Chen , Zhuoliang Chen , Jorge Garcia Fortanet , Denise Grunenfelder , Rajesh Karki , Mitsunori Kato , Matthew J. LaMarche , Lawrence Blas Perez , Travis Matthew Stams , Sarah Williams
- 申请人： Christine Hiu-Tung Chen , Zhuoliang Chen , Jorge Garcia Fortanet , Denise Grunenfelder , Rajesh Karki , Mitsunori Kato , Matthew J. LaMarche , Lawrence Blas Perez , Travis Matthew Stams , Sarah Williams
- 申请人地址： CH Basel
- 专利权人： NOVARTIS AG
- 当前专利权人： NOVARTIS AG
- 当前专利权人地址： CH Basel
- 代理商 Scott W. Reid
- 主分类号： C07D401/04
- IPC分类号： C07D401/04 ; C07D239/48 ; C07D241/26 ; C07D249/14 ; C07D401/14 ; C07D403/04 ; C07D409/14 ; C07D471/04 ; C07D487/04
摘要：
The present invention relates to compounds of formula I: in which m, Y1, Y2, Y3, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a and R5b are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.
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