In accordance with an embodiment, described herein is a system and method for use of immutable accessors with dynamic byte arrays. In accordance with an embodiment, a database driver provides access by software applications executing at an application server to data at a database, including associating a result set cache manager with a pool of result set caches. Each result set cache can be associated with one or more immutable accessors. In response to receiving a request from an application, to access a set of data, the set of data from the database is received into a particular result set cache. In response to receiving a subsequent request for a same set of data, from a same or another application using a same or another database connection, access is provided to the immutable accessor associated with the particular result set cache, for use in accessing the data therein.