Methods and techniques are described for supporting location services for a user equipment (UE) in a Fifth Generation wireless network in which a base station, such as a gNB or ng-eNB, broadcasts a Positioning Reference Signal (PRS) in a plurality of different directions and at a plurality of different times. A PRS muting configuration is used in which PRS is muted using a time based and angle based pattern to prevent interference between beams transmitted by other base stations and/or to prevent interference between beams transmitted simultaneously by a single base station. The time based and angle based muting pattern, for example, may provide an indication for each direction in the plurality of different directions and for each time in the plurality of different times and as to whether the PRS is transmitted or muted by the base station.