Invention Grant
- Patent Title: Compounds and methods for activating the apoptotic arm of the unfolded protein response
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Application No.: US15672574Application Date: 2017-08-09
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Publication No.: US10787439B2Publication Date: 2020-09-29
- Inventor: Jennifer E. Golden , Jeffrey Aube , Daniel P. Flaherty , Andrew M. Fribley , Randal J. Kaufman , Thomas D. Y. Chung , Anthony B. Pinkerton , Michael Pablo Hedrick
- Applicant: University of Kansas , The Regents of the University of Michigan , Wayne State University , Sanford-Burnham Medical Research Institute
- Applicant Address: US KS Lawrence US MI Ann Arbor US CA La Jolla US MI Detroit
- Assignee: UNIVERSITY OF KANSAS,THE REGENTS OF THE UNIVERSITY OF MICHIGAN,SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE,WAYNE STATE UNIVERSITY
- Current Assignee: UNIVERSITY OF KANSAS,THE REGENTS OF THE UNIVERSITY OF MICHIGAN,SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE,WAYNE STATE UNIVERSITY
- Current Assignee Address: US KS Lawrence US MI Ann Arbor US CA La Jolla US MI Detroit
- Agency: Licata & Tyrrell P.C.
- Main IPC: A61K31/4525
- IPC: A61K31/4525 ; C07D405/12 ; C07D307/71 ; A61K31/496 ; A61K31/5377 ; A61K45/06 ; C07C303/36
Abstract:
N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.
Public/Granted literature
- US20170334889A1 COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE Public/Granted day:2017-11-23
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