Invention Grant
- Patent Title: Fibronectin type III domain proteins with enhanced solubility
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Application No.: US14766036Application Date: 2014-02-05
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Publication No.: US10787498B2Publication Date: 2020-09-29
- Inventor: Aaron P Yamniuk , Stanley R Krystek
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- Agency: Nelson Mullins Riley & Scarborough LLP
- Agent Jane E. Remillard, Esq.; Christopher L. Frank
- International Application: PCT/US2014/014887 WO 20140205
- International Announcement: WO2014/124017 WO 20140814
- Main IPC: C07K14/435
- IPC: C07K14/435 ; C07K14/78
Abstract:
Provided herein are polypeptides comprising a modified fibronectin type III (Fn3) domain, wherein the amino acid corresponding to residue 58 of SEQ ID NO: 1 is mutated, and wherein the solubility is enhanced relative to the solubility of a Fn3 domain in which the amino acid corresponding to residue 58 of SEQ ID NO: 1 is not mutated. Also provided are libraries comprising a plurality of the polypeptides and a method for identifying a polypeptide that binds to a target.
Public/Granted literature
- US20150368319A1 FIBRONECTIN TYPE III DOMAIN PROTEINS WITH ENHANCED SOLUBILITY Public/Granted day:2015-12-24
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