Power system optimization calibration is disclosed. An example implementation includes receiving, by an engine control module, calibration information associated with optimizing an operating characteristic of a power system; determining, by the engine control module and using an optimization model, an optimization profile to optimize the operating characteristic, wherein the optimization model is configured to perform one or more optimization processes to determine, according to the calibration information, optimized values associated with adjustable parameters of the power system, wherein the optimization profile is configured to include the optimized values; and configuring, by the engine control module, a first control device, associated with a first adjustable parameter of the adjustable parameters, according to the optimization profile, wherein the first control device is configured to control a first component of an engine of the power system to be set according to an optimized value for the first adjustable parameter.