Novel techniques are described for automated physical package delivery with end-to-end package security. For example, a sender can secure contents of a physical package using an electronic lock locked using a lock code. The lock code is encrypted by applying an encryption key to generate an encrypted lock code. The encryption key is generated in accordance with a decryption key associated with the recipient, such that application of the decryption key by the recipient to the encrypted lock code can generate an unlock code to unlock the electronic lock. An intermediary automated package delivery system can provide one or more end-to-end security features, including facilitating key exchange features between the sender and recipient, applying additional sensor tag features, and directing autonomous delivery features.