- 专利标题： Immunotherapy using allo-NKT cells, cells for immunotherapy in which alpha chain of t-cell receptor (TCR) gene has been rearranged to uniform Vα-Jα, and banking of NKT cells derived from said cells
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申请号： US13991059申请日： 2011-12-02
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公开(公告)号： US10813950B2公开(公告)日： 2020-10-27
- 发明人: Masaru Taniguchi , Haruhiko Koseki , Hiroshi Watarai , Shin-ichiro Fujii
- 申请人： Masaru Taniguchi , Haruhiko Koseki , Hiroshi Watarai , Shin-ichiro Fujii
- 申请人地址： JP Wako
- 专利权人： RIKEN
- 当前专利权人： RIKEN
- 当前专利权人地址： JP Wako
- 代理机构： Leydig, Voit & Mayer, Ltd.
- 国际申请： PCT/JP2011/077990 WO 20111202
- 国际公布： WO2012/074116 WO 20120607
- 主分类号： A61K35/17
- IPC分类号： A61K35/17 ; C12N5/0783 ; C07K14/725 ; A61K45/06 ; A61K31/7028 ; C12N15/85
摘要：
The present invention provides an agent for an immunocyte therapy, comprising an NKT cell obtained by differentiating in vitro a cell having the α-chain region of the T cell receptor gene rearranged to uniform Vα-Jα in an NKT cell receptor-specific way, wherein an administration subject is an allogenic individual having MHC gene loci including at least one locus having a genotype different from that of the NKT cell. In addition, the present invention provides a bank of a human cell or an NKT cell derived from said cell, wherein the α-chain region of a T cell receptor (TCR) gene has been rearranged to uniform Vα-Jα. The agent and cell bank of the present invention are useful for the prophylaxis and/or treatment of cancer, infection, an allergic disease or an autoimmune disease.
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