- 专利标题： Retroviral transduction using poloxamers
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申请号： US15713422申请日： 2017-09-22
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公开(公告)号： US10815498B2公开(公告)日： 2020-10-27
- 发明人: Natasa Anastasov , Ines Höfig , Christian Thirion
- 申请人： HELMHOLTZ ZENTRUM MUNCHEN-DEUTSCHES FORSCHUNGS-ZE , SIRION BIOTECH GMBH
- 代理机构： Perdue IP Law, APC
- 主分类号： C12N15/867
- IPC分类号： C12N15/867 ; A61K48/00 ; C12N15/86
摘要：
The present invention relates to a method for transducing a target cell, the method comprising the step of contacting a target cell with a retroviral vector and a poloxamer having a molecular weight of 12.8 kDa to about 15 kDa. Further, the invention relates to the use of a poloxamer as defined herein, optionally in combination with a polycationic substance as defined herein, for transducing a target cell with a retroviral vector and a kit comprising a retroviral vector, a poloxamer as defined herein and, optionally, instructions for use.
公开/授权文献
- US20180016600A1 RETROVIRAL TRANSDUCTION USING POLOXAMERS 公开/授权日：2018-01-18
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