A system, computer-readable medium, and a method including obtaining flight data for a specific aircraft for a prescribed flight; obtaining current sample measurements of at least one state or output of the specific aircraft; performing based on the obtained flight data, the current measurements or outputs, and a mathematical model accurately representing an actual operational performance of the specific aircraft and providing a predictive indication of a future performance of the specific aircraft, a control optimization to determine a cost-optimal control input for the prescribed flight; adjusting, in response to a consideration of actual operational characteristics of the specific aircraft, the optimized control input; and transmitting the adjusted optimized control input to the specific aircraft to operate the specific aircraft to minimize the direct operating cost for the prescribed flight.