- 专利标题： Polymorphs and solid forms of a pyrimidinylamino-pyrazole compound, and methods of production
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申请号： US16447713申请日： 2019-06-20
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公开(公告)号： US10851088B2公开(公告)日： 2020-12-01
- 发明人: Travis Remarchuk , Anantha Sudhakar
- 申请人： Denali Therapeutics Inc.
- 申请人地址： US CA South San Francisco
- 专利权人： Denali Therapeutics Inc.
- 当前专利权人： Denali Therapeutics Inc.
- 当前专利权人地址： US CA South San Francisco
- 代理机构： Viksnins Harris Padys Malen LLP
- 主分类号： C07D403/12
- IPC分类号： C07D403/12 ; A61P25/28 ; A61K9/20
摘要：
The present disclosure relates to crystalline polymorph and amorphous forms of 2-methyl-2-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanenitrile or solvates, tautomers, and pharmaceutically acceptable salts or cocrystals thereof, and processes for their preparation.