Provided are an electronic device and a method in a radio communication system. The electronic device comprises a processing circuit. The processing circuit is configured to determine, based on information indicating inter-cell interference and information indicating intra-cell interference fed back by multiple user equipment, a transmission resource configuration regarding the multiple user equipment. According to at least one embodiment of the present disclosure, it can effectively solve the problem that system overheads for determining multi-user pairing significantly increase due to the presence of a large number of user equipment to be paired when multi-user multiple-input and multiple-output (MU-MIMO) transmission is performed, while system fairness and throughputs are also achieved.