The present disclosure provides a processing circuit of a display panel, a display method and a display device. The processing circuit includes: a line-of-sight acquisition module configured to track an eyeball of each eye, to determine a concern region of line of sight on the display panel and a region other than the concern region; a control module configured to acquire original image data of an image to be displayed on the display panel, subject first original image data corresponding to the concern region and/or second original image data corresponding to the other region to treatment, and output first image generation data corresponding to the concern region and second image generation data corresponding to the other region and having a resolution smaller than the first image generation data; and a display signal output module configured to output a display signal to the display panel in accordance with the first image generation data and the second image generation data.