Interactive detection of system anomalies is disclosed. One example is a system including a data processor, an anomaly processor, and an interaction processor. Input data related to a series of events and telemetry measurements is received by the data processor. The anomaly processor detects presence of a system anomaly in the input data, the system anomaly indicative of a rare situation that is distant from a norm of a distribution based on the series of events and telemetry measurements. The interaction processor is communicatively linked to the anomaly processor and to an interactive graphical user interface. The interaction processor displays, via the interactive graphical user interface, an output data stream based on the presence of the system anomaly, receives, from the interactive graphical user interface, feedback data associated with the output data stream, and provides the feedback data to the anomaly processor for operations analytics based on the feedback data.