Systems and methods for Optical Character Recognition (“OCR”) based anti-spoofing for Unicode homograph. The method comprises: performing operations by a computing device to make an OCR identification on an original electronic address so as to obtain an OCR electronic address; encoding (a) the original electronic address to obtain an encoded access address and (b) the OCR electronic address to obtain an encoded OCR electronic address; comparing the encoded access address to the encoded OCR electronic address; and determining if a Unicode homograph spoofing situation exists based on results of the comparing.