• Patent Title: Thiazine derivatives as β-secretase inhibitors and methods of use
  • Application No.: US16466209
    Application Date: 2017-12-13
  • Publication No.: US10889579B2
    Publication Date: 2021-01-12
  • Inventor: Matthew P. BourbeauPaul E. HarringtonQingyian Liu
  • Applicant: AMGEN INC.
  • Applicant Address: US CA Thousand Oaks
  • Assignee: AMGEN INC.
  • Current Assignee: AMGEN INC.
  • Current Assignee Address: US CA Thousand Oaks
  • Agent Markus Bergauer
  • International Application: PCT/US2017/066179 WO 20171213
  • International Announcement: WO2018/112083 WO 20180621
  • Main IPC: C07D417/10
  • IPC: C07D417/10 A61P25/28
Thiazine derivatives as β-secretase inhibitors and methods of use
Abstract:
The present disclosure provides a class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables R1, R1′, R2, R2′, R3, R4, R5, R6, R7, and b of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to Aβ plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, and other central nervous system conditions.
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