A oral treatment system that emits electromagnetic radiation onto surfaces of a user's teeth and may also dispense a oral treatment material for contact with the user's teeth. In one aspect, the oral treatment system includes a mouthpiece comprising a wall and a bite platform extending from the wall that collectively define a first channel for receiving a user's teeth; an electromagnetic radiation source coupled to the mouthpiece and configured to emit electromagnetic radiation onto surfaces of the user's teeth that are positioned in the first channel; and one or more apertures in at least one of the wall or the bite platform, the one or more apertures configured to dispense a oral treatment material to the first channel for contact with the surfaces of the user's teeth that are positioned in the first channel.